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Phoenix WinNonlins integrated tools for data processing, graphing charting, report generation, and compliance create an efficient, all-in-one collaboration workbench.

It is the industry standard for non-compartmental analysis (NCA), pharmacokineticpharmacodynamic (PKPD), and toxicokinetic (TK) modeling with a proven 30-year history.

I have opened almost all of my 6.1 projects in 6.2 now, and can confirm that always the NCA was pinky.

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Trial Simulator. Software validation - Pharsight Computer System Validation and Pharsight Validation Products Debra Fontana, Quality Assurance Manager Jason Chittenden, Product Marketing Manager All contents Copyright 2006 Pharsight Corporation.

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Dear all, Recently we have upgraded our phoenix WinNonlin software from 6.1 to 6.2.

Now after installation, whenever I reopen my earlier calculated project (Done on WinNonlin Version 6.1), each time NCA object in workflow and its respective NCA parameters output displays in red color.

If I repeat the same calculation again in new version, it doesnt show red highlighted background.

Can anyone explain me the correct procedure if I am going wrong Thanks in advance.

Tushar, when you say repeat the analysis in 6.2 do you mean you refreshed i.e.

Re-executed the existing red NCA object If so then you are doing the correct process.

Essentially Phoenix is suggesting there maybe a change in settings between 6.1 and 6.2 and is indicating you should re-execute the results.

For NCA I cant think of anything that would cause that, however in a Phoenix model there are known enhancements that are highlighted to the user when opening a 6.1 project in 6.2.

There is one unusual thing in your workflow I noted; why have you linked the BE object to a copy of the Final Parameters file in the data folder - this means that the data is now static whereas the expected way to build that workflow would be to link the NCA final parameters sheetdirectly to the BE tool Ive attached an example of the suggestion - Can you out of interest open this 6.1 project and tell me what you see in 6.2 Simon.

NewTrialBElinked.phxproj size428456 file.

Tushar, my guess is you are using Internet Explorer as Ive heard some other users complain about this too; that attachment is a normal Phoenix project - however it seems some browsers rename the file when downloading, simply rename the extension back to.phxproj and open in Phoenix.

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Please confirm your browser type and if this works, sorry for the problems -were looking at how to fix these issues in the forum (I know the latest posts link is also somewhat unresponsive currently and I have a request to address that too).

Dear Sdavis, From your first reply, where you were asking about repeat calculation, I meant if I completely repeat the study (i.e.

From inputting data of concentration into data folder to till BE object) in version 6.2.

That time it doesnt show red highlighted results.

Same way you mentioned, if I re-execute the workflow of earlier studies in new version then also result doesnt get highlighted.

Is it new feature of WinNonlin 6.2 (to Eexecute workflow) Because in last version I couldnt find it any The attachment you have provided is accessible after changing its extension.

In that, NCA and Bioequivalence both objects are red highlighted in new version.

But after re-executing the total workflow, it displays as normal.

Finally, As far as that unusual thing in my workflow is concern, actually I had tried my best to connect BE tool directly to NCA object but couldnt find the way to add period and sequence column in Final parameteer pivoted sheet (in NCA output).

By using this technique provided by you, I got the same results as compared to yours, except AUC values.

Because you have utilized Linear Up and Log Down method for AUC calculation whereas I have used Linear Trapezoidal Linear Interpolation method.

Many thanks to you and Helmut for your kind replies Regards, Tushar.

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